Technology - AlphaVision® for Medical (AVM) is a software platform for blending (integrating) multiple data sets into a single actionable 3D Landscape using the power of GPUs. Through interactive data shaping, the user is empowered to conduct exploratory analysis and ask questions of the data with immediate answers.
cBioPortal is a powerful exploratory tool for large datasets. AVM is also an exploratory tool that enhances the cBioPortal experience by empowering users to do things not possible with static charts and tables.
AVM can be launched directly from any cBioPortal installation to visualize any table data. (Pending integration detailed in RFC.)
AVM allows the user to instantly see all of the data concurrently by converting it into a massive interactive 3D Landscape. In cBioPortal, the result of a comparison analysis is often available in static 2D charts and tables of data, which may show a subset of data at a time.
This visual analysis allows the user to tap their mind’s eye to recognize outliers and discover patterns not otherwise visible. Outliers, such as genes with a high fold change, immediately jump out at us
The camera controls for exploring the 3D Landscape and inspecting individual data points are presented through a familiar interface.
The 3D Landscapes can be both interactively inspected and manipulated through the data shaping tools. Data is mapped to visual attributes such as height, color and position, which can be changed on-the-fly. The user can also dynamically filter the visible data. This allows the user to ask and get immediate answers. A powerful formula language is available for more complex questions.
With genomic data, run pathway analysis to rearrange the Landscape and look at pathways in the context of the original data.
AVM features a patented Data Model to integrate (blend and aggregate) different types of data so it can be viewed side-by-side. With cBioPortal, multiple datasets for a study can be loaded (e.g. mRNA, methylation, mutations, CNA), based on sample groupings (or cohorts) defined in the cBioPortal interface.
This is particularly powerful in answering biological questions dynamically which can lead to experiment design modifications, new ideas on drug targets and clinical trials. When a biologist is looking at different types of data side-by-side (e.g. mRNA next to mutations next to methylation), biological patterns can become apparent. They can then drill-down to the underlying data. For example, if a given cohort has a high mutation frequency in a particular gene, drill down to the actual mutations.
Request access - Evaluation licenses are available for Windows users to install AVM for cBioPortal: .
